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As the rainwater dumped by Matthew flows downriver, towns are being overwhelmed by devastating floods. "You're dealing with just massive amounts of water," one reporter says.
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Rain accumulations of 8 to 12 inches are possible from northeast South Carolina into northeast North Carolina and southeast Virginia, the National Hurricane Center says.
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The last major hurricane, defined as Category 3 and stronger, to hit the mainland U.S. was Hurricane Wilma, which made landfall in Florida in 2005. Matthew could break that lucky streak.
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Hurricane Matthew drowned and battered the island nation on Tuesday. At least 283 people died and, more than 48 hours after the storm made landfall, many of the worst hit areas are still inaccessible.
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Hundreds of people died as Hurricane Matthew struck Haiti, Cuba and the Bahamas. The National Hurricane Center says the hurricane conditions will affect eastern Florida through Friday.
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Hurricane Matthew killed at least 11 people in Haiti before it barreled north toward the Bahamas. Florida, Georgia and the Carolinas all declared states of emergency as they prepared for the storm.
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The Category 4 storm dumped rain on southwestern Haiti on Tuesday morning and lashed the island with maximum sustained winds of up to 145 mph. The hurricane is continuing north toward Cuba.
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Authorities warn of "life threatening" wind and flooding in Haiti and have issued warnings for parts of Cuba, Haiti and Jamaica. The U.S. Navy evacuated families from its base at Guantanamo Bay, Cuba.
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Hurricane conditions could hit Jamaica and Haiti by Monday, with tropical storm conditions possible by late Sunday, The National Hurricane Center says.