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David Letterman appears during the Wednesday taping of his final <em>Late Show With David Letterman</em> at the Ed Sullivan Theater in New York.

Letterman Fills Final Show With Memories And Gratitude

David Letterman approached his final extra-long hour of late night TV on Wednesday with the same self-deprecation as the previous 6,000-plus, but leavened the snark with heaps of nostalgia and praise.

Sales of prescription opioid painkillers have quadrupled since 1999, according to the Centers for Disease Control and Prevention.

Maine Bill Aims To Make Abuse-Deterrent Painkillers More Affordable

Expensive versions of prescription opioids that are tougher to cut, crush and inject are less likely to be abused, legislators hope. But some doctors call the bill well-meant, but ill-advised.

An Author Of Paper About Changing Minds On Gay Marriage Seeks Retraction

The paper, published in Science, suggested conversations could increase support for same-sex marriage. Researchers who tried to replicate the study say the data were not collected as described.

FIFA President Sepp Blatter kicks a ball during the inauguration of a football stadium in the village of Dura al-Qari near the West Bank city of Ramallah on Wednesday. Blatter said he is on a "mission of peace" to resolve tensions between the Israeli and Palestinian soccer federations.

For Israel, Soccer Becomes A Geopolitical Football

The head of FIFA visited Israel and the West Bank this week, where Palestinians are petitioning to expel Israel from soccer's governing body — and its biggest international tournaments.

Murals on display across the street from the Red Bull House of Art gallery in Detroit, Mich. After the largest municipal bankruptcy in U.S. history, Detroit hopes outsiders will focus on the city's potential, not the history of conflict and crisis that has cut its population in half since 1960.

#MotorCityDrive: Is Detroit's Economic Engine Roaring Back To Life?

Michel Martin heads to Detroit for a live conversation with some of the creative forces fueling the Motor City's economy. She'll ask: What's driving Detroit's future now?

A photo released on Sunday by the Syrian official news agency SANA shows a general view of the ancient Roman city of Palmyra, northeast of Damascus, Syria. Fears have intensified that the self-declared Islamic State, which captured the city on Wednesday, might raze the ruins.

Fears Grow That ISIS Might Target Palmyra's Ancient Treasures

Ancient ruins in the Syrian city captured by Islamist extremists could suffer the same fate as priceless artifacts that were destroyed in other cities seized by the group.

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